02 / 2026 FORTBILDUNG: THEMENHEFTTEIL KINDERÄRZTE. SCHWEIZ 29 87 Hoffmann, K.; Hainzl, A.; Stingl, M.; et al. «Interdisziplinäres, kollaboratives D-A-CH Konsensus-Statement zur Diagnostik und Behandlung von Myalgischer Enzephalomyelitis/ Chronischem Fatigue-Syndrom». Wiener Klinische Wochenschrift 2024;136(Suppl 5):103–123. doi.org/10.1007/s00508-02402372-y (abgerufen am 18. Mai 2026). 88 Stingl, M. «Pragmatische Diagnostik und Therapie bei Long Covid». neurostingl.at (abgerufen am 18. Mai 2026). 89 Holtzman, C. S.; Bhatia, S.; Cotler, J.; Jason, L. A. «Assessment of Post-Exertional Malaise (PEM) in Patients with Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS): A Patient-Driven Survey». Diagnostics (Basel) 2019;9(1):26. doi. org/10.3390/diagnostics9010026 (abgerufen am 18. Mai 2026). 90 Jäkel, B.; Kedor, C.; Grabowski, P.; et al. «Hand grip strength and fatigability: correlation with clinical parameters and diagnostic suitability in ME/CFS». Journal of Translational Medicine 2021;19(1):159. doi.org/10.1186/s12967-021-02774-w (abgerufen am 18. Mai 2026). 91 Lange, G.; Lin, J. S.; Chen, Y.; et al. «Cognitive assessment in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a cognitive substudy of the multi-site clinical assessment of ME/ CFS (MCAM)». Frontiers in Neuroscience 2024;18:1460157. doi. org/10.3389/fnins.2024.1460157 (abgerufen am 18. Mai 2026). 92 Keller, B.; Receno, C. N.; Franconi, C. J.; et al. «Cardiopulmonary and metabolic responses during a 2-day CPET in myalgic encephalomyelitis/chronic fatigue syndrome: translating reduced oxygen consumption to impairment status to treatment considerations». Journal of Translational Medicine 2024;22(1):627. doi. org/10.1186/s12967-024-05410-5 (abgerufen am 18. Mai 2026). 93 Wright, J.; Astill, S. L.; Sivan, M. «The Relationship between Physical Activity and Long COVID: A Cross-Sectional Study». International Journal of Environmental Research and Public Health 2022;19(9):5093. doi.org/10.3390/ijerph19095093 (abgerufen am 18. Mai 2026). 94 Twomey, R.; DeMars, J.; Franklin, K.; Culos-Reed, S. N.; Weatherald, J.; Wrightson, J. G. «Chronic Fatigue and Postexertional Malaise in People Living With Long COVID: An Observational Study». Physical Therapy 2022;102(4):pzac005. doi.org/10.1093/ ptj/pzac005 (abgerufen am 18. Mai 2026). 95 Plash, W. B.; Diedrich, A.; Biaggioni, I.; et al. «Diagnosing postural tachycardia syndrome: comparison of tilt testing compared with standing haemodynamics». Clinical Science (London) 2013;124(2):109–114. doi.org/10.1042/CS20120276 (abgerufen am 18. Mai 2026). 96 Ebert, Hans-Holger; et al. Der Synkopenlotse. Thieme, Stuttgart, 2009. doi.org/10.1055/b-0034-40563 (abgerufen am 18. Mai 2026). 97 Seeley, M. C.; Gallagher, C.; Ong, E.; et al. «High Incidence of Autonomic Dysfunction and Postural Orthostatic Tachycardia Syndrome in Patients with Long COVID: Implications for Management and Health Care Planning». The American Journal of Medicine 2023. doi.org/10.1016/j.amjmed.2023.06.010 (abgerufen am 18. Mai 2026). 98 Buoite Stella, A.; Furlanis, G.; Frezza, N. A.; Valentinotti, R.; Ajcevic, M.; Manganotti, P. «Autonomic dysfunction in post-COVID patients with and without neurological symptoms: a prospective multidomain observational study». Journal of Neurology 2022;269(2):587–596. doi.org/10.1007/s00415-02110735-y (abgerufen am 18. Mai 2026). 99 Shah, B.; Kunal, S.; Bansal, A.; et al. «Heart rate variability as a marker of cardiovascular dysautonomia in post-COVID-19 syndrome using artificial intelligence». Indian Pacing and Electrophysiology Journal 2022;22(2):70–76. doi.org/10.1016/j. ipej.2022.01.004 (abgerufen am 18. Mai 2026). 100 Tahir, F.; Bin Arif, T.; Majid, Z.; Ahmed, J.; Khalid, M. «Ivabradine in Postural Orthostatic Tachycardia Syndrome: A Review of the Literature». Cureus 2020;12(4):e7868. doi.org/10.7759/ cureus.7868 (abgerufen am 18. Mai 2026). 101 Ruzieh, M.; Baugh, A.; Dasa, O.; et al. «Effects of intermittent intravenous saline infusions in patients with medication-refractory postural tachycardia syndrome». Journal of Interventional Cardiac Electrophysiology 2017;48(3):255–260. doi.org/10.1007/s10840017-0225-y (abgerufen am 18. Mai 2026). 102 Snapper, H.; Cheshire, W. P. «Oral and intravenous hydration in the treatment of orthostatic hypotension and postural tachycardia syndrome». Autonomic Neuroscience 2022;238:102951. doi.org/10.1016/j.autneu.2022.102951 (abgerufen am 18. Mai 2026). 103 Medow, M. S.; Guber, K.; Chokshi, S.; Terilli, C.; Visintainer, P.; Stewart, J. M. «The Benefits of Oral Rehydration on Orthostatic Intolerance in Children with Postural Tachycardia Syndrome». The Journal of Pediatrics 2019;214:96–102. doi.org/10.1016/j. jpeds.2019.07.041 (abgerufen am 18. Mai 2026). 104 Arun, S.; Storan, A.; Myers, B. «Mast cell activation syndrome and the link with long COVID». British Journal of Hospital Medicine (London) 2022;83(7):1–10. doi.org/10.12968/ hmed.2022.0123 (abgerufen am 18. Mai 2026). 105 «Signs and Symptoms of Mast Cell Activation Syndrome». MastCellActivationSyndrome.org. www.mastcellactivationsyndrome.org (abgerufen am 18. Mai 2026). 106 Weinstock, L. B.; Brook, J. B.; Walters, A. S.; Goris, A.; Afrin, L. B.; Molderings, G. J. «Mast cell activation symptoms are prevalent in Long-COVID». International Journal of Infectious Diseases 2021;112:217–226. doi.org/10.1016/j.ijid.2021.09.043 (abgerufen am 18. Mai 2026). 107 Ramsay, D. B.; Stephen, S.; Borum, M.; Voltaggio, L.; Doman, D. B. «Mast cells in gastrointestinal disease». Gastroenterology & Hepatology (New York) 2010;6(12):772–777. 108 Hennigs, J. K.; Huwe, M.; Hennigs, A.; et al. «Respiratory muscle dysfunction in long-COVID patients». Infection 2022;50(5):1391– 1397. doi.org/10.1007/s15010-022-01840-9 (abgerufen am 18. Mai 2026). 109 Evbuomwan, O.; Endres, W.; Tebieia, T.; Engelbrecht, G. «Incidence and follow-up of persistent lung perfusion abnormalities as a result of suspected air trapping or microthrombosis in non-hospitalised COVID-19 patients during the early half of the pandemic - experience in a tertiary institution in South Africa». South African Medical Journal 2022;112(11):850–854. doi. org/10.7196/SAMJ.2022.v112i11.16578 (abgerufen am 18. Mai 2026). 110 Laubscher, G. J.; Lourens, P. J.; Venter, C.; Kell, D. B.; Pretorius, E. «TEG®, Microclot and Platelet Mapping for Guiding Early Management of Severe COVID-19 Coagulopathy». Journal of Clinical Medicine 2021;10(22):5381. doi.org/10.3390/jcm10225381 (abgerufen am 18. Mai 2026). 111 Fedorowski, A.; Fanciulli, A.; Raj, S. R.; et al. «Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden». Nature Reviews Cardiology 2024. doi. org/10.1038/s41569-023-00962-3 (abgerufen am 18. Mai 2026). 112 Puntmann, V. O.; Martin, S.; Shchendrygina, A.; et al. «Longterm cardiac pathology in individuals with mild initial COVID-19 illness». Nature Medicine 2022;28(10):2117–2123. doi.org/ 10.1038/s41591-022-02000-0 (abgerufen am 18. Mai 2026). 113 Mehta, P.; Bunker, C. B.; Ciurtin, C.; et al. «Chilblain-like acral lesions in long COVID-19: management and implications for understanding microangiopathy». The Lancet Infectious Diseases 2021;21(7):912. doi:10.1016/S1473-3099(21)00133-X. 114 Li, J.; Zhou, Y.; Ma, J.; et al. «The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of long COVID». Signal Transduction and Targeted Therapy 2023;8(1):416. doi.org/10.1038/s41392-023-01640-z (abgerufen am 18. Mai 2026). 115 Yale School of Medicine. «Potential New Treatment for ‹Brain Fog› in Long COVID Patients». 12.12.2022. URL: https://medicine.yale.edu/news-article/potential-new-treatment-for-brain-fogin-long-covid-patients/ (abgerufen am 18. Mai 2026).
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